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As of October 2015, she had a net worth of US$1.85 billion.
Wyss served on the board of directors of Synthes from 2008 to 2012, when it was sold to Johnson & Johnson. She co-founded the Twirl Toy Store in Taos, New Mexico. She was also a co-founder of the Golden Willows Retreat, a bereavement center in Arroyo Hondo, New Mexico. In 2007, Wyss and her husband, Ed Jaramillo, established the LOR Foundation.
Wyss served on the board of trustees of the National Outdoor Leadership School and was a member of the board of directors for the Wyss Foundation In 2007, Wyss and her husband, Ed Jaramillo, established the LOR Foundation, a grant-making organization dedicated to improving livability in rural communities across the Intermountain West through community-driven conservation.