After Martin ended its run in 1997, Lawrence found work in comedy films. He often starred as the second lead opposite actors including Eddie Murphy, Danny DeVito, and Tim Robbins. Many of his films were blockbusters at the box office, including Nothing to Lose, Life, Blue Streak, and Big Momma's House. He also starred in critical- and box-office failures, including Black Knight and National Security. Regardless, his salary steadily increased to over $10 million per film role. He continues to work in film, with such films as Big Momma's House 2, which opened at No. 1 at North American box office and grossed almost $28 million its first weekend, and Wild Hogs (2007), in which he played a bored suburbanite seeking adventure on the open road in a biker comedy alongside John Travolta, Tim Allen and William H. Macy.
In January 1997, Lawrence's Martin co-star Tisha Campbell-Martin filed a lawsuit against him, alleging sexual harassment and abuse both on and off set. By April 1997, Campbell had settled the lawsuit, and returned to appear in the last two episodes of the series. In March 1997, Lawrence was arrested after punching a man in a Hollywood nightclub.