In 2010, Green donated $465,000 for new beds at the Royal Marsden Cancer Hospital, after his wife Tina's mother died there. He also spent more than $150,000 for an Alexander McQueen dress at Naomi Campbell's Fashion for Relief charity event. In the same year, Green donated £100,000 to the Evening Standard's Dispossessed Fund which aims to support London's poorest people.
In August 2010, Green was asked by Cameron, then recently elected as Prime Minister, to carry out a review of UK government spending and procurement. Green's summary report, Efficiency Review by Sir Philip Green, published in October 2010, alleged significant failings in government procurement processes. The government published the review identifying its main finding as "the Government is failing to leverage both its credit rating and its scale". Cameron welcomed the report, saying "I think it's a good report, it will save a lot of money and it's important we do it."
Green became the target of activist group UK Uncut in November 2010 for alleged corporate tax avoidance. The group targeted Green specifically as a government advisor.
In 2010, Green was again accused of using sweatshops, this time by Channel 4's Dispatches programme. It was asserted that he was using factories in Britain in which workers were paid less than half the legal minimum wage.