In June 2011, Stricker won at the Memorial Tournament in Ohio, his tenth tour title. He opened with 68 and bettered this with 67 in the second round. However, this was made special by the hole-in-one he recorded at the par three 8th hole to hold a three stroke advantage at the halfway stage. Remarkably, he then opened round three with two eagles in the first five holes to open up a six-shot lead midway through round three, but some uncharacteristic mistakes on the back nine saw him fall back towards the rest of the field. He held on to the 36-hole lead to eventually win by one stroke over runners-up Matt Kuchar and Brandt Jobe. With this victory, Stricker became the highest-ranked American in the Official World Golf Ranking, at fourth in the world. For the first time in his career, 44-year-old Stricker was ranked higher than all other American golfers, including Tiger Woods and Phil Mickelson. Stricker played the tournament at −20 for the front nine, a record by 6 shots, versus +4 for the back nine.
Stricker tied a major championship record with a 63 in the first round at the PGA Championship in 2011, and led by two shots. His next three days were 74-69-73, and he tied for twelfth. Stricker's career earnings are over $44 million through the end of the 2018–19 season, among the highest of those without a major title.